DNA Digest: Fats
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DNA Digest: Fats

Did you know that our genes can impact how our bodies process and metabolise fats? In this blog, we'll explore the basics of fat sensitivity, the genetics behind it, and how we can optimise our fat intake based on our genetic makeup.

So, let's get started! 

What is fat sensitivity?

Fat sensitivity refers to the body's ability to process and metabolise fats. Individuals with high-fat sensitivity may have difficulty breaking down and utilising fats, leading to weight gain. 

What are the genes involved in fat sensitivity?

Several genes have been identified that can impact how the body processes and metabolises fats. For example, variations in the PPARG gene have been linked to an increased risk of obesity and impaired lipid metabolism. Variations in the FTO gene have also been associated with differences in response to dietary fat.

How can we optimise our fat intake based on our genetics?

One way to optimise fat intake is through genetic testing. By identifying genetic variations that impact fat metabolism, individuals can tailor their fat intake to best support their unique needs. For example, individuals with variations in the APOA2 gene may benefit from limiting their intake of saturated fats, such as those found in red meat and high-fat dairy products.

What are some sources of fat?

Fat can be found in a wide range of foods, including meats, dairy products, nuts, seeds, and oils. Some common sources of fat include avocado, salmon, olive oil, and nuts.

What are some Signs of Fat Sensitivity?

Signs of fat sensitivity can include weight gain, high cholesterol levels, and difficulty losing weight. Individuals with fat sensitivity may also experience digestive issues after consuming high-fat meals.

What are some strategies for managing fat sensitivity?

One strategy for managing fat sensitivity is to focus on consuming healthy fats, such as those found in fish, nuts and avocados. Additionally, pairing fats with fibre-rich foods and protein can help slow the absorption of fat into the bloodstream.

It's also worth noting that not all fats are created equal. While healthy fats, such as those found in nuts and seeds, can provide numerous health benefits, unhealthy fats, such as those found in processed foods and deep-fried foods, can have negative impacts on our health.

So, next time you're reaching for that handful of nuts or cooking up some salmon, remember that your genes could be influencing how your body processes and metabolises those fats.

Our genes can play a role in determining our sensitivity to fats and our optimal fat intake. By staying informed about our unique genetic makeup and paying attention to our body's response to different types of fats, we can make informed choices to support our health and well-being.


Corella D, Peloso G, Arnett DK, et al. APOA2, dietary fat, and body mass index: replication of a gene-diet interaction in 3 independent populations. Arch Intern Med. 2009;169(20):1897-1906. doi:10.1001/archinternmed.2009.329

Flores-Sierra J, Ariza AC, Velasco-Cruz M, et al. Genetic variants in the promoter region of the adiponectin encoding gene (ADIPOQ) as predictors for adiponectin concentrations, insulin resistance, and the metabolic syndrome in Mexican children. Diabetes Metab Res Rev. 2012;28(4):338-345. doi:10.1002/dmrr.2281

Liu Z, Qi Q, Wu Y, et al. Variants in the LEPR gene are significantly associated with higher BMI and lower adiponectin levels in individuals with impaired glucose tolerance. Hum Genet. 2010;128(3):267-275. doi:10.1007/s00439-010-0859-9

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